Health benefits of Grifola frondosa polysaccharide on intestinal microbiota in type 2 diabetic mice

Xiaoxiang Gao; Dan Liu; Luying Gao; Yuezhen Ouyang; Yuxi Wen; Chao Ai; Yuqing Chen; Chao Zhao

Food Science and Human Wellness (Jan 2022)

Health benefits of Grifola frondosa polysaccharide on intestinal microbiota in type 2 diabetic mice

Xiaoxiang Gao,
Dan Liu,
Luying Gao,
Yuezhen Ouyang,
Yuxi Wen,
Chao Ai,
Yuqing Chen,
Chao Zhao

Affiliations

Xiaoxiang Gao: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Dan Liu: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Luying Gao: Department of Pediatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Yuezhen Ouyang: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Yuxi Wen: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Chao Ai: School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Department of Food Science & Technology, National University of Singapore, Singapore 117543, Singapore
Yuqing Chen: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Chao Zhao: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou 350002, China; Corresponding author at: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Journal volume & issue: Vol. 11, no. 1
pp. 68 – 73

Abstract

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Grifola frondosa polysaccharide (GFP) as the natural compounds have been reported to exert diverse bioactivities. The aim of this study was to investigate the regulatory effects of GFP on intestinal microbiota in type 2 diabetic mice. The changes of microbiota in faeces of the diabetic mice upon high fat diet were determined and the V3 region of the 16S rRNA was sequenced by Illumina MiSeq high-throughput sequencing platform. Eighty operational taxonomic unit were identified to be shared by all samples, and the quality and richness of sequencing were assessed via rarefaction and rank abundance curves. The diversity of gut flora was slightly improved in diabetic mice after GFP treatment. The composition and relative abundance of gut microbiota at phylum and genus levels were altered by GFP. The abundance of Robinsoniella, Flavonifractor, Anaerotruncus, and Desulfvibrio were found to concentrate on diabetic mice through LEfSe analysis. Furthermore, Alloprevotella and Burkholderia had strong relevancy with other gut flora. Based on the findings, GFP might be a desired candidate on ameliorating the intestinal unbalance in diabetes.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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