Journal of Functional Foods (Jun 2024)
Agaricus blazei murrill and Enteromorpha prolifera-derived polysaccharides gain therapeutic effects on esophageal squamous cell carcinoma
- Yong Lin,
- Xinxin Li,
- Jing Zhao,
- Penghu Liu,
- Yijian Zhou,
- Yongpan Liu,
- Dai Lin,
- Liang Bu,
- Zhuo Wang,
- Hongzhou Zhao,
- Shihui Zhang,
- Yuxuan Wei,
- Jiaying Zhang,
- Bo Zhang,
- Jialing Xie,
- Xiaolu An,
- Lijia Zhang,
- Pingfa Lin,
- Kun Zhang,
- Kuancan Liu
Affiliations
- Yong Lin
- Science and Technology Service Center, Fujian Health College, Fuzhou, Fujian 350101, PR China
- Xinxin Li
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Jing Zhao
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Penghu Liu
- National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China
- Yijian Zhou
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Yongpan Liu
- School of Life Science, Xiamen University, Xiamen, Fujian, 361102, PR China
- Dai Lin
- Department of Nutrition and Food Safety, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350122, PR China
- Liang Bu
- Department of Thoracic Surgery, Institute of Chest and Lung Disease, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Zhuo Wang
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Hongzhou Zhao
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Shihui Zhang
- Centre for Translational Stem Cell Biology, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR 999077, PR China
- Yuxuan Wei
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Jiaying Zhang
- School of Life Science, Xiamen University, Xiamen, Fujian, 361102, PR China
- Bo Zhang
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Jialing Xie
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Xiaolu An
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Lijia Zhang
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China
- Pingfa Lin
- Science and Technology Service Center, Fujian Health College, Fuzhou, Fujian 350101, PR China
- Kun Zhang
- Department of General Surgery, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian 350009, PR China; Corresponding authors at: School of Medicine, Xiamen University, Xiamen, Fujian 361102, China (Kuancan Liu).
- Kuancan Liu
- Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, PR China; Corresponding authors at: School of Medicine, Xiamen University, Xiamen, Fujian 361102, China (Kuancan Liu).
- Journal volume & issue
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Vol. 117
p. 106244
Abstract
Esophageal squamous cell carcinoma (ESCC), the most common pathological type of esophageal cancer, is one of the leading causes of cancer death worldwide, but an effective therapeutic avenue is still absent. This study was to evaluate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) and Enteromorpha prolifera polysaccharides (EP) on ESCC. The results showed that both ABP and EP have therapeutic effects on multiple malignant processes of ESCC, such as proliferation, migration, invasion, and apoptosis, in vitro. Moreover, both ABP and EP retard tumor growth in vivo and the growth of ESCC-derived organoids. A series of genes and proteins changed upon treatments with ABP and EP after RNA sequencing and proteomics analysis. Autophagy, mitophagy and ferroptosis were enriched after treatments with these two polysaccharides, suggesting that the consumption of ABP and EP may represent a promising dietary supplement for ESCC therapy.
