In vitro neuroprotective effects and in silico evaluation of the pharmacological potential of two phenolic acids and a derivative originated from the edible red macroalga (Bangia fuscopurpurea)

Abstract

Most previous studies on the bioactive substances from the edible red macroalga (Bangia fuscopurpurea) have concentrated on the polysaccharides and proteins. We explored the possible effects of two phenolic acids (HBP2—3) and two derivatives (HBP1 and HBP4) originated from Bangia fuscopurpurea and two structural analogues in an in vitro model of Parkinson’s disease. We also performed in silico evaluation of the pharmacological potential of these six compounds. Our present study showed that HBP1—3 had neuroprotective effects. Moreover, HBP3 (10 nM) could protect SH-SY5Y cells from 6-hydroxydopamine (6-OHDA) damage via activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) cascade, and the up-regulation of this pathway could inhibited reactive oxygen species (ROS) production. In addition, we speculated the preliminary structure–activity relationships on the neuroprotective effects of HBP1—3. This study demonstrated that neuroprotective effects of HBP1—3 originated from Bangia fuscopurpurea.

Keywords

• Bangia fuscopurpurea
• Parkinson’s disease
• Butyl isobutyl phthalate
• Methyl 2,4-dihydroxyphenylacetate
• Methyl 2-(3-hydroxyphenyl)acetate
• Structure–activity relationships