Polysaccharide extracted from Morchella esculenta inhibits carrageenan-induced thrombosis in mice

Guilan Chen; Yingquan Liang; Dandan Wang; Feng Zhang; Rong Huang; Yu Ge; Chenzhong Liao; Xuegong Hao; Yuanli Chen; Jihong Han; Xiaoxiao Yang; Yajun Duan

Journal of Functional Foods (Oct 2022)

Polysaccharide extracted from Morchella esculenta inhibits carrageenan-induced thrombosis in mice

Guilan Chen,
Yingquan Liang,
Dandan Wang,
Feng Zhang,
Rong Huang,
Yu Ge,
Chenzhong Liao,
Xuegong Hao,
Yuanli Chen,
Jihong Han,
Xiaoxiao Yang,
Yajun Duan

Affiliations

Guilan Chen: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Yingquan Liang: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Dandan Wang: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230013, China
Feng Zhang: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Rong Huang: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Yu Ge: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Chenzhong Liao: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Xuegong Hao: Anhui Miao De Tang Pharmaceutical Co. Ltd., Fuyang 236400, China
Yuanli Chen: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Jihong Han: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin 300071, China
Xiaoxiao Yang: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; Corresponding authors.
Yajun Duan: Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; Corresponding authors.

Journal volume & issue: Vol. 97
p. 105235

Abstract

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Thrombosis is one of the leading causes of death worldwide and is associated with inflammation and oxidative stress. This study aims to investigate the effect of Morchella esculenta Polysaccharide (MCP) on thrombosis. Our results showed that MCP inhibited thrombi in blood vessels of mouse tail, liver and lung, which was contributed by the inhibition of collagen accumulation, tumor necrosis factor-α and P-selectin expression. In vitro, human platelet clot retraction test indicated that MCP inhibited platelet activation, which was related to inhibition of platelet receptors, AKT and ERK1/2 pathways. Additionally, MCP inhibited oxidative stress by inducing anti-oxidative enzymes in human platelets and human umbilical vein vascular endothelium cells (HUVECs). Moreover, MCP inhibited oxidized low-density lipoprotein or LPS-induced adhesion of monocytes to HUVECs by reducing adhesion molecules expression. Taken together, these data demonstrate MCP exhibits antithrombotic properties, indicating Morchella esculenta can be used as food supplements and nutraceuticals against thrombosis.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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