Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study

Yawen Wang; Yi Zheng; Xin Zhang; Jincheng Li; Yucan Li; Chengjun Zhang; Ningxin Gao; Jiacheng Wang; Min Fan; Weizhong Tian; Yanfeng Jiang; Yingzhe Wang; Mei Cui; Chen Suo; Tiejun Zhang; Li Jin; Xingdong Chen; Kelin Xu

Journal of Functional Foods (Jan 2025)

Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study

Yawen Wang,
Yi Zheng,
Xin Zhang,
Jincheng Li,
Yucan Li,
Chengjun Zhang,
Ningxin Gao,
Jiacheng Wang,
Min Fan,
Weizhong Tian,
Yanfeng Jiang,
Yingzhe Wang,
Mei Cui,
Chen Suo,
Tiejun Zhang,
Li Jin,
Xingdong Chen,
Kelin Xu

Affiliations

Yawen Wang: Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China
Yi Zheng: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China
Xin Zhang: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China
Jincheng Li: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China
Yucan Li: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China
Chengjun Zhang: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China
Ningxin Gao: Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China
Jiacheng Wang: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China
Min Fan: Taixing Disease Control and Prevention Center, Taizhou, Jiangsu, China
Weizhong Tian: Taizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu, China
Yanfeng Jiang: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
Yingzhe Wang: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
Mei Cui: Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
Chen Suo: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
Tiejun Zhang: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
Li Jin: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
Xingdong Chen: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; Yiwu Research Institute of Fudan University, Yiwu, Zhejiang, China; Corresponding author at: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China.
Kelin Xu: Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; Corresponding author at: Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.

Journal volume & issue: Vol. 124
p. 106632

Abstract

Read online

The DASH dietary pattern has been shown to decrease systolic blood pressure (SBP), whereas the mechanisms remain incompletely understood. The objective of this cross-sectional study was to ascertain whether serum metabolites mediated the association between the DASH diet and SBP utilizing non-targeted metabolomic techniques in the Taizhou Imaging Study. The DASH score was calculated using data collected by food frequency questionnaires. Adherence to the DASH diet was linked to lower SBP (β = −2.61; 95 % CI: −4.12, −1.20). It was observed that lipid and lipoprotein metabolites suppressed the relationship between the DASH score and SBP (The ratio of suppressing effect was 0.059). Moreover, acetic acid and glucose demonstrated significant mediation effects in the parallel mediation model (The proportion of mediation effect was 22.87 %). Among the components of the DASH diet, we revealed that 2 subfractions of very low-density lipoprotein had suppression effects, while acetic acid mediated the association between vegetable intake and SBP. These findings provide evidence for indirect effects of serum metabolites in the influence of DASH diet on SBP.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords