Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats

Journal of Acute Disease. 2013;2(4):304-309 DOI 10.1016/S2221-6189(13)60149-3

 

Journal Homepage

Journal Title: Journal of Acute Disease

ISSN: 2221-6189 (Print); 2589-5516 (Online)

Publisher: Wolters Kluwer Medknow Publications

Society/Institution: Hainan Medical University

LCC Subject Category: Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid

Country of publisher: India

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB

 

AUTHORS

Jayachandran Muthukumaran (Department of Biochemistry, Adhiparasakthi College of Arts and Science, G. B. Nagar, Kalavai, Vellore Dist – 632506, Tamil Nadu, India)
Subramani Srinivasan (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608002, Tamil Nadu, India)
Rantham Subramaniyam Venkatesan (Department of Biochemistry, Adhiparasakthi College of Arts and Science, G. B. Nagar, Kalavai, Vellore Dist – 632506, Tamil Nadu, India)
Vinayagam Ramachandran (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608002, Tamil Nadu, India)
Udaiyar Muruganathan (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608002, Tamil Nadu, India)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

Objective: To evaluate the antidiabetic effect of syringic acid, a natural phenolic compound on the levels of glycoprotein components in plasma and tissues of alloxan induced diabetic rats. Methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of alloxan (150 mg/kg b.w). Syringic acid (50 mg/kg b.w) was administered orally for 30 d. The effects of syringic acid on plasma glucose, insulin, C-peptide, plasma and tissue glycoproteins were studied. Results: Oral administration of syringic acid (50 mg/kg b.w) for 30 d positively modulates the glycemic status in alloxan induced diabetic rats. The levels of plasma glucose were decreased with significant increase of plasma insulin and C-peptide level. The altered levels of plasma and tissue glycoprotein components were restored to near normal. No significant changes were noticed in normal rats treated with syringic acid. Conclusions: The present findings suggest that syringic acid can potentially ameliorate glycoprotein components abnormalities in addition to its antidiabetic effect in experimental diabetes, further clinical studies are required to evaluate the use of syringic acid as an effective therapeutic agent for the treatment of diabetes mellitus.