Phosphatidic acid production regulated by receptors with liganddependent tyrosine kinase activity

Abstract

The present study deals with the most recent and important studies on the relationship between transmembrane receptors with ligand-dependent tyrosine kinase activity and cellular lipid metabolism, predominantly in generating phosphatidic acid (PA) as a lipid messenger. The signaling function of phosphatidylcholine hydrolysis and diacylglycerol (DG) phosphorylation by phospholipase D and diacylglycerol kinase, respectively, as different sources for PA is also described. PA may play a role in signal transduction as a putative first or second messenger, and acts to reduce levels of DG and to produce bis-PA by phospholipase D - mediated transphosphatidylation.

Keywords

• diacylglycerol kinase
• information (paper)
• ptiospfiatidic acid
• phospholipase d
• recepto
• tyrosine kinase activity