ALTERNATIVE AND COMPLEMENTARY SYNTHETIC APPROACHES TO β CARBOXY-α-METHYLENE-γ-BUTYROLACTONE ETHYL ESTERS

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry. 2011;12(4):323-340

 

Journal Homepage

Journal Title: Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry

ISSN: 1582-540X (Print)

Publisher: Alma Mater Publishing House "Vasile Alecsandri" University of Bacau

Society/Institution: "Vasile Alecsandri" University of Bacau

LCC Subject Category: Technology: Chemical technology

Country of publisher: Romania

Language of fulltext: French, English

Full-text formats available: PDF

 

AUTHORS

Gwenaëlle Liberge
Stéphane Lebrun
Axel Couture
Pierre Grandclaudon

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 6 weeks

 

Abstract | Full Text

Alternative synthetic approaches to a variety of β substituted and carboxylated α-methylene-γ-butyrolactones have been developed. In the first approach the mandatory methylene unit was incorporated on precursor compounds at early stage of the synthesis on reliance with Horner-Emmons protocol. In the alternative approach which further tolerates multifarious substituents at γ-position of the lactone template the unsaturated moiety α to the lactone carbonyl group is connected at a later stage through a deprotonation / methoxymethylation / elimination sequence.