Cholesterol-lowering effect of Lactobacillus plantarum NCU116 in a hyperlipidaemic rat model

Chuan Li; Shao-Ping Nie; Qiao Ding; Ke-Xue Zhu; Zhi-Jun Wang; Tao Xiong; Joshua Gong; Ming-Yong Xie

Journal of Functional Foods (May 2014)

Cholesterol-lowering effect of Lactobacillus plantarum NCU116 in a hyperlipidaemic rat model

Chuan Li,
Shao-Ping Nie,
Qiao Ding,
Ke-Xue Zhu,
Zhi-Jun Wang,
Tao Xiong,
Joshua Gong,
Ming-Yong Xie

Affiliations

Chuan Li: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Shao-Ping Nie: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Corresponding author. Tel.: +86 791 88304452; fax: +86 791 88304452.
Qiao Ding: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Ke-Xue Zhu: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Zhi-Jun Wang: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Tao Xiong: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Joshua Gong: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Guelph Food Research Center, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario N1G 5C9, Canada
Ming-Yong Xie: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Corresponding author. Tel.: +86 791 83969009; fax: +86 791 83969009.

Journal volume & issue: Vol. 8
pp. 340 – 347

Abstract

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The cholesterol-lowering effect of Lactobacillus plantarum (L. plantarum) NCU116 on lipid metabolism of rats fed on a high fat diet was investigated. Sprague-Dawley rats were randomly divided into normal diet (ND) group, a high fat diet (HFD) group, HFD plus L. plantarum NCU116 groups with two different doses (NCU116-L, 108 colony forming units (CFU)/mL; NCU116-H, 109 CFU/mL). After treatment for 5 weeks, L. plantarum NCU116 had the potential ability to regulate lipid metabolism levels, morphology of liver and adipose tissues. In addition, the bacterium significantly improved gene expression of low-density lipoprotein (LDL) receptor and cholesterol 7α-hydroxylase (CYP7A1). These results suggest that L. plantarum NCU116 was able to alter lipid metabolism and reduce the cholesterol level, in particular, in the rats on a high fat diet through regulating gene expression of key factors relating to LDL receptor and CYP7A1.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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