The ethanolic extract of Korean Curcuma longa rhizome inhibits adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obese mice via activating AMPK signaling pathway

Abstract

The present study aimed to evaluate the anti-obesity effect of the ethanolic extract of Korean Curcuma longa (CLE) on 3T3-L1 adipocytes and high-fat diet (HFD)-induced obesity in mouse. CLE treatment suppressed lipid accumulation and restored the differentiation-induced changes in adipogenesis- and lipolysis-related proteins by recovering phosphorylation of AMP-activated protein kinase (AMPK). Moreover, in CLE-administered HFD-induced mouse model, body weight and lipid accumulation were reduced, and the changes in factors related to adipogenesis and lipolysis were regulated in the adipose and liver tissues, confirming that these effects were due to a restoration in the phosphorylation of AMPK. In summary, these results provide important insights into the anti-obesity role of CLE by demonstrating its anti-obesity effects on adipocytes and obese mouse models, thereby suggesting the potential application of CLE as a preventive agent for obesity.

Keywords

• Anti-obesity
• Curcuma longa
• 3T3-L1 adipocytes
• C57BL/6N mice model
• AMP-activated protein kinase