npj Vaccines
(Nov 2021)
Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
Chaojie Zhong,
Hongjie Xia,
Awadalkareem Adam,
Binbin Wang,
Renee L. Hajnik,
Yuejin Liang,
Grace H. Rafael,
Jing Zou,
Xiaofang Wang,
Jiaren Sun,
Lynn Soong,
Alan D. T. Barrett,
Scott C. Weaver,
Pei-Yong Shi,
Tian Wang,
Haitao Hu
Affiliations
Chaojie Zhong
Department of Microbiology and Immunology, University of Texas Medical Branch
Hongjie Xia
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Awadalkareem Adam
Department of Microbiology and Immunology, University of Texas Medical Branch
Binbin Wang
Department of Microbiology and Immunology, University of Texas Medical Branch
Renee L. Hajnik
Department of Microbiology and Immunology, University of Texas Medical Branch
Yuejin Liang
Department of Microbiology and Immunology, University of Texas Medical Branch
Grace H. Rafael
Department of Microbiology and Immunology, University of Texas Medical Branch
Jing Zou
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Xiaofang Wang
Department of Microbiology and Immunology, University of Texas Medical Branch
Jiaren Sun
Department of Microbiology and Immunology, University of Texas Medical Branch
Lynn Soong
Department of Microbiology and Immunology, University of Texas Medical Branch
Alan D. T. Barrett
Department of Pathology, University of Texas Medical Branch
Scott C. Weaver
Department of Microbiology and Immunology, University of Texas Medical Branch
Pei-Yong Shi
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Tian Wang
Department of Microbiology and Immunology, University of Texas Medical Branch
Haitao Hu
Department of Microbiology and Immunology, University of Texas Medical Branch
DOI
https://doi.org/10.1038/s41541-021-00405-5
Journal volume & issue
Vol. 6,
no. 1
pp.
1
– 7
Abstract
Read online
Abstract A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine diminished viral loads and lung inflammation in mice after SARS-CoV-2 challenge, which correlated with the T-cell response induced by the vaccine in the lung, indicating that T-cell immunity is also likely critical for protection against SARS-CoV-2 infection in addition to neutralizing antibodies.
Published in npj Vaccines
ISSN
2059-0105 (Online)
Publisher
Nature Portfolio
Country of publisher
United Kingdom
LCC subjects
Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website
https://www.nature.com/npjvaccines/
About the journal
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