Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice

Jia-Ni Lin; Pei-Sheng Lee; Nai-Wen Mei; An-Chin Cheng; Roch-Chui Yu; Min-Hsiung Pan

Food Science and Human Wellness (Dec 2019)

Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice

Jia-Ni Lin,
Pei-Sheng Lee,
Nai-Wen Mei,
An-Chin Cheng,
Roch-Chui Yu,
Min-Hsiung Pan

Affiliations

Jia-Ni Lin: Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, China
Pei-Sheng Lee: Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, China
Nai-Wen Mei: GINCARE Int'l Enterprises Co., Ltd., No. 24, Sec. 3, Chungyang Rd., Tu-Cheng Dist., New Taipei City, 23673, Taiwan, China
An-Chin Cheng: Department of Tourism, Food and Beverage Management, Chang Jung Christian University, Tainan 71101, Taiwan, China
Roch-Chui Yu: Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, China
Min-Hsiung Pan: Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, China; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, China; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, China; Corresponding author at: Institute of Food Science and Technology, National Taiwan University, 1, Sec. 4, Roosevelt Rd., Taipei, 106, Taiwan, China.

Journal volume & issue: Vol. 8, no. 4
pp. 344 – 350

Abstract

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Excess caloric intake increases the amount of adipose tissue and contributes to metabolic disorders in disrupted metabolic homeostasis. This study aimed to investigate the anti-obesity effects of ginseng and the alternation of gut microbiota composition in high-fat diet (HFD)-induced obesity. The results showed that HFD treatment influenced body weight gain, adipose tissue accumulation and biochemical parameter changes. Compared to the HFD group, ginseng supplementation of HFD-fed mice decreased body weight, adipose tissue mass, total cholesterol (T-CHO) and high-density lipoprotein (HDL)/low-density lipoprotein (LDL) ratio. To analysis the alterations of gut microbiota, ginseng in dietary supplements decreased Firmicutes abundance and increased Bacteroidetes abundance. Taken together, these findings suggest ginseng may modulate the energy storage and alter gut microbiota composition. Keywords: Ginseng, High-fat diet, Obesity, Gut microbiota

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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