Phloridzin alleviate colitis in mice by protecting the intestinal brush border and improving the expression of sodium glycogen transporter 1

Abstract

Increasing reports showed that artificial food additives might increase the incidence of ulcerative colitis (UC). Phloridzin is a natural food additive and a pharmacologic agent, whether phloridzin could induce or treat UC is not clear. We investigated the effects of phloridzin on acute colitis in mice and elucidated the potential mechanism. Phloridzin was given to mice with acute UC induced by 4% dextran sulfate sodium orally (60 mg/kg) and daily. Body weight, food and water intake and disease activity index scores were recorded every day. The colon length and thickness, and histopathological changes were determined after mice being sacrificed. Data showed that phloridzin could improve the symptoms of acute colitis, protect the intestinal brush border, and may raise the expression of sodium glycogen transporter 1, phospho-p38MAPK and Ezrin, resulting in promoting the activation and transportation of Na+/H+ exchanger. Therefore, phloridzin may be a food additive and dietary supplementary of UC.

Keywords

• Phloridzin
• Ulcerative colitis
• NHE3
• SGLT1
• Food additive