The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin

Abstract

The effects of the methanolic extracts of Filipendula hexapetala Gilib. aerial parts (FHA) and roots (FHR) against cisplatin induced kidney and liver injuries in rats were investigated as well as determination of genotoxicity and antigenotoxicity of the extracts. Treatment with FHA and FHR significantly decreased levels of urea, uric acid, serum transaminases, alkaline phosphatase and γ-glutamyl transferase, and increased the content of total protein. In addition, treatment with the extracts significantly attenuated the cisplatin-induced oxidative stress in kidney and liver tissues by increasing catalase and superoxide dismutase activities and the content of reduced glutathione and decreasing the content of thiobarbituric acid reactive substances (TBARS). The histopathological studies confirmed the protective effects of the extracts against cisplatin-induced kidney and liver injuries. The extracts ameliorated cisplatin-induced genotoxicity. These results suggest that F. hexapetala extracts are effective nephro- and hepatoprotective agents, with potential to reduce oxidative stress and ameliorate cisplatin-induced nephro- and hepatotoxicity.

Keywords

• Filipendula hexapetala
• HPLC analysis
• Cisplatin
• Nephrotoxicity
• Hepatotoxicity
• Antigenotoxic effect