Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin

Abstract

Milk fat globule membrane (MFGM) was found to possess anti-cancer, anti-obesity and anti-inflammatory activities. The present study was carried out to evaluate the effects and possible underlying mechanisms of MFGM on type 2 diabetes (T2D) in mice. Results showed that 8-week MFGM supplementation had beneficial effects in ameliorating hyperglycemia and dyslipidemia in T2D mice induced with a high-fat diet and streptozotocin. MFGM also protected the liver and pancreas histological structures in T2D mice. Additionally, MFGM enhanced glycogen synthesis, which was associated with inhibition of glycogen synthase kinase 3 beta and activation of glycogen synthase. Furthermore, a mechanistic study illuminated that MFGM likely ameliorated glucose metabolism disorder by promoting the phosphatidylinositol 3-kinase/protein kinase B pathway while suppressing c-Jun N-terminal kinase signaling in liver and skeletal muscle. These findings suggest that MFGM may be useful as a potential functional food ingredient against diabetes.

Keywords

• Milk fat globule membrane
• Type 2 diabetes
• PI3K/Akt signalling pathway
• Glycogen synthesis
• Glucolipid metabolism