Bacupari peel extracts (Garcinia brasiliensis) reduce high-fat diet-induced obesity in rats

Maria Eliza de Castro Moreira; Dorina Isabel Gomes Natal; Renata Celi Lopes Toledo; Natalia Medina Ramirez; Sonia Machado Rocha Ribeiro; Laércio dos Anjos Benjamin; Leandro Licursi de Oliveira; Dayana Alves Rodrigues; Jacinto Demuner Antônio; Marcia Paranho Veloso; Marcelo Henrique Dos Santos; Hercia Stampini Duarte Martino

Journal of Functional Foods (Feb 2017)

Bacupari peel extracts (Garcinia brasiliensis) reduce high-fat diet-induced obesity in rats

Maria Eliza de Castro Moreira,
Dorina Isabel Gomes Natal,
Renata Celi Lopes Toledo,
Natalia Medina Ramirez,
Sonia Machado Rocha Ribeiro,
Laércio dos Anjos Benjamin,
Leandro Licursi de Oliveira,
Dayana Alves Rodrigues,
Jacinto Demuner Antônio,
Marcia Paranho Veloso,
Marcelo Henrique Dos Santos,
Hercia Stampini Duarte Martino

Affiliations

Maria Eliza de Castro Moreira: Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil; Corresponding author at: Universidade Federal de Viçosa (UFV), Departamento de Nutrição e Saúde, Cep: 36570-000, Viçosa, MG, Brazil.
Dorina Isabel Gomes Natal: Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Renata Celi Lopes Toledo: Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Natalia Medina Ramirez: Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Sonia Machado Rocha Ribeiro: Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Laércio dos Anjos Benjamin: Department of Veterinary, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Leandro Licursi de Oliveira: Department of General Biology, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Dayana Alves Rodrigues: Department of Chemistry, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Jacinto Demuner Antônio: Department of Chemistry, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Marcia Paranho Veloso: Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-000, Brazil
Marcelo Henrique Dos Santos: Department of Chemistry, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil
Hercia Stampini Duarte Martino: Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36571-000, Brazil

Journal volume & issue: Vol. 29
pp. 143 – 153

Abstract

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The aim of this study was to determine the effect of ethanol extract of bacupari peel (EEB) on the adiposity and inflammation modulation in obese Wistar rats. The group treated with high fat diet plus EEB (BHFD) presented weight gain, visceral fat, and lee, and an adiposity index similar to the negative control group (AIN-93M). Also, the BHFD group showed antioxidant and anti-inflammatory effect, increase of peroxisome proliferator activated receptor-γ (PPAR-γ) and Interleukin-10 (IL-10) expression, and decreasing expression of lipoprotein lipase (LPL) and fatty acid synthase (FAS), and reduced the tumor necrosis factor-α (TNF-α), blood levels of glucose, alanine aminotransferase, and adipocyte hypertrophy. The molecular docking showed that morelloflavone and 7-epiclusianone compounds from bacupari extract interacted with PPAR-γ receptor, hydrophobic interaction, indicating an agonist activity of these compounds. Thus, we demonstrated that extract of bacupari presented anti-obesity activities.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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