Yacon flour (Smallanthus sonchifolius) attenuates intestinal morbidity in rats with colon cancer

Mariana Grancieri; Neuza Maria Brunoro Costa; Maria das Graças Vaz Tostes; Daniela Silva de Oliveira; Louisiane de Carvalho Nunes; Letícia de Nadai Marcon; Thaísa Agrizzi Veridiano; Mirelle Lomar Viana

Journal of Functional Foods (Oct 2017)

Yacon flour (Smallanthus sonchifolius) attenuates intestinal morbidity in rats with colon cancer

Mariana Grancieri,
Neuza Maria Brunoro Costa,
Maria das Graças Vaz Tostes,
Daniela Silva de Oliveira,
Louisiane de Carvalho Nunes,
Letícia de Nadai Marcon,
Thaísa Agrizzi Veridiano,
Mirelle Lomar Viana

Affiliations

Mariana Grancieri: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil; Corresponding author at: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, P.O. Box: 16, 29500-000 Alegre, ES, Brazil.
Neuza Maria Brunoro Costa: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil
Maria das Graças Vaz Tostes: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil
Daniela Silva de Oliveira: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil
Louisiane de Carvalho Nunes: Department of Veterinary Medicine, Center of Agrarian Sciences and Engineering, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil
Letícia de Nadai Marcon: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil
Thaísa Agrizzi Veridiano: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil
Mirelle Lomar Viana: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil

Journal volume & issue: Vol. 37
pp. 666 – 675

Abstract

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Yacon flour (YF) (Smallanthus sonchifolius) is source of fructooligosaccharides (FOS) which are prebiotic with effects unknown in the colorectal cancer (CRC). This study investigated the intestinal effects of supplementation with 7.5% FOS from YF for 8 weeks on CRC induced by 1.2-dimethylhydrazine (25 mg/kg/body weight) in male Wistar rats. The animals were divided in groups: S (without YF and without induced CRC, n = 10), Y (with YF and without induced CRC, n = 10), C (without YF and with induced CRC, n = 10) and CY (with YF and with induced CRC, n = 10). The animals that received YF had a percentage reduction of aberrant crypts focus in more than 40%, lower intestinal permeability, luminal content more acidic and with higher concentrations of SCFA. In addition, there was an increase in the depth and number of colonic crypts. In conclusion, we observed that YF promoted beneficial effects on the intestinal health of animals with induced CRC.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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