Effect of biodegradable and synthetic polymer combination on release behaviour of Nateglinide from matrix tablets.

Abstract

The present work was to study the effect of biodegradable and synthetic polymers on sustained release (SR) matrix tablets of Nateglinide by in vitro performance. The SR tablets were formulated with various concentrations of chitosan and/ or Eudragit RLPO or HPMC K100M via direct compression. The tablets were subjected to tests for drug-polymer interaction, weight variation, thickness, hardness, friability, drug content, in vitro drug release and stability studies. The NG06 SR matrix tablets formulated was able to sustain the release of the drug over 12 hours (CDR=98% ± 1.47) and shown optimum post-compression properties. In vitro release data of NG06 also showed a good linear relationship in the Korsmeyer-Peppas model (r2=0.9975) while n=0.750 indicated non-Fickian transport. The optimized formulation, NG06, which consisted of 12.5mg Chitosan and 12.5mg Eudragit RLPO, had the best characteristics to achieve the aims of this study.