Dietary strategies to promote the abundance of intestinal Akkermansia muciniphila, a focus on the effect of plant extracts

Chenbo Yue; Chuanqi Chu; Jianxin Zhao; Hao Zhang; Wei Chen; Qixiao Zhai

Journal of Functional Foods (Jun 2022)

Dietary strategies to promote the abundance of intestinal Akkermansia muciniphila, a focus on the effect of plant extracts

Chenbo Yue,
Chuanqi Chu,
Jianxin Zhao,
Hao Zhang,
Wei Chen,
Qixiao Zhai

Affiliations

Chenbo Yue: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Chuanqi Chu: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Jianxin Zhao: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Hao Zhang: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, China
Wei Chen: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China
Qixiao Zhai: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; Corresponding author at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.

Journal volume & issue: Vol. 93
p. 105093

Abstract

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As the next generation of probiotics, Akkermansia muciniphila has attracted a lot of attention and research because of its probiotic properties. However, it is not on the list of strains that can be added to food in any country, and its sensitivity to oxygen and the availability of animal-derived media limit its industrial production. Alternative dietary intervention strategies have broad application prospects. This review uses plant extracts as the main framework to summarize studies on increasing the abundance of A. muciniphila in recent years. Polyphenols, alkaloids, capsaicin, plant-derived carbohydrates, and some Chinese medicines can significantly increase the abundance of A. muciniphila in the gut. Promoting the abundance of A. muciniphila's mechanisms focused on promoting the secretion of mucins and their antibacterial ability. This paper provides a lot of theoretical basics for the development of dietary strategies that can improve intestinal A. muciniphila abundance in the future.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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