npj Vaccines (Jul 2024)

A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses

  • Syamala Rani Thimmiraju,
  • Rakesh Adhikari,
  • JeAnna R. Redd,
  • Maria Jose Villar,
  • Jungsoon Lee,
  • Zhuyun Liu,
  • Yi-Lin Chen,
  • Suman Sharma,
  • Amandeep Kaur,
  • Nestor L. Uzcategui,
  • Shannon E. Ronca,
  • Wen-Hsiang Chen,
  • Jason T. Kimata,
  • Bin Zhan,
  • Ulrich Strych,
  • Maria Elena Bottazzi,
  • Peter J. Hotez,
  • Jeroen Pollet

DOI
https://doi.org/10.1038/s41541-024-00924-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 5

Abstract

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Abstract The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.