Study on Dendrobium officinale O-acetyl-glucomannan (Dendronan): Part IV. Immunomodulatory activity in vivo

Xiaojun Huang; Shaoping Nie; Hailan Cai; Guanya Zhang; Steve W. Cui; Mingyong Xie; Glyn O. Phillips

Journal of Functional Foods (May 2015)

Study on Dendrobium officinale O-acetyl-glucomannan (Dendronan): Part IV. Immunomodulatory activity in vivo

Xiaojun Huang,
Shaoping Nie,
Hailan Cai,
Guanya Zhang,
Steve W. Cui,
Mingyong Xie,
Glyn O. Phillips

Affiliations

Xiaojun Huang: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Shaoping Nie: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Corresponding author. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Tel.: +86 791 88304452; fax: +86 791 88304452.
Hailan Cai: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Guanya Zhang: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Steve W. Cui: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario, NIG 5C9, Canada; Corresponding author. Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario, NIG 5C9, Canada. Tel.: +1 226 217 8076; fax: +1 519 780 2600.
Mingyong Xie: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Glyn O. Phillips: Glyn O. Phillips Hydrocolloid Research Centre, Glyndŵr University, Wrexham LL11 2AW, UK; Phillips Hydrocolloids Research Ltd., 45 Old Bond Street, London W1S 4QT, UK

Journal volume & issue: Vol. 15
pp. 525 – 532

Abstract

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As part of a series of studies on the bioactivities and structures of polysaccharides from Dendrobium officinale, this study investigates the immunomodulatory activities of Dendrobium officinale and its two polysaccharide fractions (crude and purified, respectively) in cyclophosphamide induced mice. All three materials protected the body from immunosuppression in a dose-dependent manner. Biological activities related to immunomodulations investigated included stimulating the proliferation of splenocytes, balancing the ratio of spleen lymphocyte subsets and the secretion of serum cytokines, up-regulating the serum IgM, IgG and haemolysin formation, and accelerating the phagocytotic function of peritoneal macrophage. The degree of modulations were higher in purified Dendrobium officinale polysaccharide than crude polysaccharide, indicating that the purified polysaccharide was one of the key bioactive components in Dendrobium officinale, the main structure of which has been identified as O-acetyl-glucomannan (Dendronan)

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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