The effect of flaxseed supplementation on glycemic control in adults: An updated systematic review and meta-analysis of randomized controlled trials

Zeynab Kavyani; Parisa Pourfarziani; Amir Mohamad Jafari Kakhki; Sana Sedgh Ahrabi; Amir Hossein Moridpour; Negar Mollaghasemi; Vali Musazadeh; Amir Hossein Faghfouri

Journal of Functional Foods (Nov 2023)

The effect of flaxseed supplementation on glycemic control in adults: An updated systematic review and meta-analysis of randomized controlled trials

Zeynab Kavyani,
Parisa Pourfarziani,
Amir Mohamad Jafari Kakhki,
Sana Sedgh Ahrabi,
Amir Hossein Moridpour,
Negar Mollaghasemi,
Vali Musazadeh,
Amir Hossein Faghfouri

Affiliations

Zeynab Kavyani: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
Parisa Pourfarziani: Islamic Azad University of Pharmaceutical Sciences, Tehran, Iran
Amir Mohamad Jafari Kakhki: Faculty of Medicine, Shahid Sadoughi University of Medical Sicences,Yazd, Iran
Sana Sedgh Ahrabi: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Amir Hossein Moridpour: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Negar Mollaghasemi: Department of Nutrition, School of Medical Sciences and Technologies, Islamic Azad University of Science and Research Branch, Tehran, Iran
Vali Musazadeh: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding authors at: Assistant Professor of Nutrition, Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran (Amir Hossein Faghfouri) Master of Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran (Vali Musazadeh).
Amir Hossein Faghfouri: Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran; Corresponding authors at: Assistant Professor of Nutrition, Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran (Amir Hossein Faghfouri) Master of Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran (Vali Musazadeh).

Journal volume & issue: Vol. 110
p. 105816

Abstract

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Recent randomized controlled trials (RCTs) have shown that flaxseed supplementation beneficially improves glycemic control; however, there is no consensus on this issue. In this systematic review and meta-analysis, we aimed to investigate the effect of flaxseed and its products on glycemic control in adults. We searched PubMed, Scopus, Embase, Web of Science databases, and Google Scholar till December 2022. Finding from forty-seven RCTs revealed that flaxseed supplementation had a statistically significant reduction in FBS (SMD: −0.66; 95% CI: −0.96, −0.35), HOMA-IR (SMD: −0.64; 95% CI: −1.02, −0.26), and insulin (SMD: −0.49; 95% CI: −0.80, −0.17). Besides, QUICKI increased significantly (SMD: 1.64; 95% CI: 1.13, 2.14) following flaxseed supplementation. Additionally, flaxseed did not change the HbA1c (SMD: −0.47; 95% CI: −0.97, 0.04) significantly. The present meta-analysis suggests flaxseed supplementation can improve FBS, QUIKI, HOMA-IR, and insulin levels but not HbA1c. Overall, flaxseed can be used as an adjuvant anti-hyperglycemic agent.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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