Plasma lipid lowering effect by a novel chia seed based nutraceutical formulation

Abstract

Atherosclerotic cardiovascular diseases (ASCVD) are preferential targets of preventive medicine partially through therapies to improve atherogenic lipid profiles. The aim of the present work was to test a novel nutraceutical formulation (CSN) for its potential effects on plasma triglyceride levels of healthy subjects with moderate dyslipidemia. A cohort of 52 individuals were administered daily, for 8 weeks, with four gastro-resistant capsules of CSN, each one containing 500 mg of cryo-micronized chia seeds and 15 mg of vitamin E, according to a single centre, randomized, placebo controlled, 16 weeks trial. Data showed the following mean lipid changes: triglycerides, −27.5% (P = .0095); total cholesterol, −8.0% (P = .0019); High Density Lipoprotein cholesterol, +5.7% (P = .0042); Low Density Lipoprotein cholesterol, −10.2% (P = .0021). CSN may be regarded as a novel complementary and/or alternative safe remedy with clinical relevance in the primary cardiovascular disease prevention.

Keywords

• Nutraceutical
• Chia seeds
• PUFA
• Dyslipidemia
• Plasma triglycerides