Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial

Andrew Pipingas; Andrew Sinclair; Kevin D. Croft; Andrzej S. Januszewski; Alicia J. Jenkins; Trevor A. Mori; Robyn Cockerell; Natalie A. Grima; Con Stough; Andrew Scholey; Stephen P. Myers; Avni Sali; Matthew P. Pase

Journal of Functional Foods (Dec 2015)

Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial

Andrew Pipingas,
Andrew Sinclair,
Kevin D. Croft,
Andrzej S. Januszewski,
Alicia J. Jenkins,
Trevor A. Mori,
Robyn Cockerell,
Natalie A. Grima,
Con Stough,
Andrew Scholey,
Stephen P. Myers,
Avni Sali,
Matthew P. Pase

Affiliations

Andrew Pipingas: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia; Corresponding author. Centre for Human Psychopharmacology, Swinburne University of Technology, ATC Building. PO Box 218, Hawthorn, 3122, Australia. Tel.: +61 3 9214 5215.
Andrew Sinclair: School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia
Kevin D. Croft: School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Andrzej S. Januszewski: Department of Medicine (St. Vincent's), The University of Melbourne, Parkville, Australia; NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Sydney, Australia
Alicia J. Jenkins: Department of Medicine (St. Vincent's), The University of Melbourne, Parkville, Australia; NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Sydney, Australia
Trevor A. Mori: School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Robyn Cockerell: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia
Natalie A. Grima: Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia
Con Stough: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia
Andrew Scholey: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia
Stephen P. Myers: NatMed-Research Unit, Division of Research, Southern Cross University, Lismore, NSW 2480, Australia
Avni Sali: National Institute of Integrative Medicine, Hawthorn 3122, Australia
Matthew P. Pase: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia

Journal volume & issue: Vol. 19
pp. 949 – 957

Abstract

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The effects of daily fish oil supplementation, with and without multivitamins, on biochemical markers of health were examined. Healthy adults (N = 160) were randomised to receive 3 g of salmon oil with a multivitamin, 6 g of salmon oil with a multivitamin, 6 g of salmon oil in isolation or placebo in a double-blind fashion on a daily basis for 16 weeks. Relative to placebo, both 6 g salmon oil groups displayed significantly lower F2-isoprostane levels at endpoint. Increases in red blood cell polyunsaturated fatty acids correlated with reductions in F2-isoprostanes. Treatment had no effect on inflammatory cytokines, C-reactive protein, fibrinogen, cholesterol or triacylglycerol.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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