Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice

Kaiyue Liu; Ke Zhang; Yang Yang; Ying Zong; Zhongmei He; Weijia Chen; Jianming Li; Rui Du

Journal of Functional Foods (Jan 2025)

Effects of sika deer antler protein on immune regulation and intestinal microbiota in mice

Kaiyue Liu,
Ke Zhang,
Yang Yang,
Ying Zong,
Zhongmei He,
Weijia Chen,
Jianming Li,
Rui Du

Affiliations

Kaiyue Liu: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
Ke Zhang: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
Yang Yang: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
Ying Zong: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China; Corresponding authors at: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Zhongmei He: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China
Weijia Chen: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China
Jianming Li: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China
Rui Du: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Jilin Agricultural University, Changchun 130118, China; Corresponding authors at: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.

Journal volume & issue: Vol. 124
p. 106637

Abstract

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The medicinal use of pilose antler was first described in Shennong's Classic of Materia Medica for treating kidney yang deficiency. Therefore, in this study, sika deer antler protein (SDAP) was used as a component analysis and its impacts on the immunomodulatory effects of RAW264.7 cells and kidney yang deficiency mice, as well as the intestinal flora of mice, were investigated. The results showed that SDAP could regulate the secretion of associated factors and the expression of genes and proteins of NF-κB-related signaling pathway in RAW264.7 cells induced by lipopolysaccharide and kidney yang deficiency mice. Additionally, SDAP could regulate intestinal homeostasis by increasing the abundance of beneficial bacteria Lactobacillus and Clostridium, reducing the abundance of pathogenic bacteria Proteobacteria, and maintaining some bacterial homeostasis in kidney-yang deficiency mice, so as to decrease intestinal edema, effectively improve intestinal microecology, and improve the immune function of the organism.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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