Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose

Shuwen Lei; Zhifang Zhang; Guihua Xie; Chunyan Zhao; Yue Miao; Dehong Chen; Guangren Zhang; Hao Liu; Chunxiu Peng; Yan Hou; Jiashun Gong

Journal of Functional Foods (Feb 2022)

Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose

Shuwen Lei,
Zhifang Zhang,
Guihua Xie,
Chunyan Zhao,
Yue Miao,
Dehong Chen,
Guangren Zhang,
Hao Liu,
Chunxiu Peng,
Yan Hou,
Jiashun Gong

Affiliations

Shuwen Lei: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Zhifang Zhang: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Guihua Xie: College of Tea, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Chunyan Zhao: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Yue Miao: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Dehong Chen: College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Guangren Zhang: College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Hao Liu: College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Chunxiu Peng: College of Horticulture and Landscape, Yunnan Agricultural University, Kunming, Yunnan 650201, China
Yan Hou: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China; College of Tea, Yunnan Agricultural University, Kunming, Yunnan 650201, China; Corresponding authors at: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China.
Jiashun Gong: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China; Corresponding authors at: College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China.

Journal volume & issue: Vol. 89
p. 104941

Abstract

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Theabrownin (TB) is a complex oxidized polyphenol formed during the microbial fermentation of Pu-erh tea. It offers some health benefits such as weight loss, blood glucose reduction, and oxidation resistance; however, the anti-aging effect and the related mechanism have not yet been explored. In this study, symptoms of aging were induced in mice using D-galactose. Morris water maze test, hematoxylin-eosin staining, 16S rDNA high-throughput sequencing, and UHPLC-QE-MS metabolomics were used to reveal the anti-aging effects and potential mechanism of TB. TB improved the learning and memory ability, the liver oxidative stress (SOD, GSH-Px, and MDA), inflammation (IL-2, IL-6, and TNF-α), and degeneration of the small intestine in the aging mice. Further analysis showed that TB pretreatment increased the relative abundance of Lactobacillus_murinus and Bacteroides_acidifaciens, and regulated 19 metabolites in the serum. In addition, TB treatment increased the relative abundance of Akkermansia_muciniphila, and regulated 12 metabolites. In conclusion, the anti-aging effect of TB is exerted by the targeted regulation of intestinal microorganisms, which could prevent and delay aging.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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