Fermentation (Apr 2025)

Microbial Poly-Glutamic Acid: Production, Biosynthesis, Properties, and Their Applications in Food, Environment, and Biomedicals

  • Verma Manika,
  • Palanisamy Bruntha Devi,
  • Sanjay Pratap Singh,
  • Geereddy Bhanuprakash Reddy,
  • Digambar Kavitake,
  • Prathapkumar Halady Shetty

DOI
https://doi.org/10.3390/fermentation11040208
Journal volume & issue
Vol. 11, no. 4
p. 208

Abstract

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This review offers an in-depth analysis of microbial γ-poly-glutamic acid (γ-PGA), highlighting its production, biosynthetic pathways, unique properties, and extensive applications in the food and health industries. γ-PGA is a naturally occurring biopolymer synthesized by various microorganisms, particularly species of Bacillus. The report delves into the challenges and advancements in cost-effective production strategies, addressing the economic constraints associated with large-scale γ-PGA synthesis. Its biocompatibility, biodegradability, and non-toxic nature make it a promising candidate for diverse industrial applications. γ-PGA’s exceptional water-holding capacity and humectant properties are key to its utility in the food industry. These features enable it to enhance the stability, viscosity, and shelf life of food products, making it a valuable ingredient in processed foods. The review highlights its ability to improve the textural quality of baked goods, stabilize emulsions, and act as a protective agent against staling. Beyond food applications, γ-PGA’s role in health and pharmaceuticals is equally significant. Its use as a drug delivery carrier, vaccine adjuvant, and biofilm inhibitor underscores its potential in advanced healthcare solutions.

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