Astaxanthin lowers blood pressure and lessens the activity of the renin-angiotensin system in Zucker Fatty Rats

Abstract

The ability of astaxanthin to favorably influence the renin-angiotensin system (RAS), blood pressure (BP), and metabolic parameters in Zucker Fatty Rats (ZFR) was examined. In separate experiments, 96 ZFR were equally divided into four groups: control, captopril (30 mg/kg), low astaxanthin (5 mg/kg) and high astaxanthin (25 mg/kg). RAS and insulin systems were examined following recovery from heat stress. RAS was lower in test groups; however, there was no evidence of enhanced insulin sensitivity. Test groups decreased SBP (systolic blood pressure) significantly compared to the control. The tests carried out suggested that RAS was involved in the ability of astaxanthin to lower BP. Astaxanthin at high dosage influenced circulating TNF-α and MCP-1 and lessened fat oxidation in liver and kidneys. Thus, astaxanthin may be considered as a good stress reducer with regards to heat stress. Astaxanthin’s effects on RAS indicate it might overcome perturbations associated with increased activity, especially those related to the cardiovascular system.

Keywords

• Astaxanthin
• Angiotensin-2
• Renin-angiotensin
• Captopril
• Metabolism
• Blood pressure