Journal of Acute Disease (Jul 2024)

Expression level of interferon-stimulated genes PKR, OAS1, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients: A retrospective study

  • Elham Jafari Maskouni,
  • Samaneh Abbasi,
  • Elham Mousavi,
  • Zahra Najafimemar,
  • Ali Mohammad Arabzadeh,
  • Mehrdad Farrokhnia,
  • Saeedeh Ebrahimi

DOI
https://doi.org/10.4103/jad.jad_64_24
Journal volume & issue
Vol. 13, no. 3
pp. 111 – 115

Abstract

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Objective: To explore expression level of interferon-stimulated genes PKR, OASI, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients. Methods: In this study, changes in the expression of four interferon-stimulated genes (ISGs), including PKR, OASI, MX1, and ISG15, in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR method. Results: OASI, MX1, PKR, and ISG15 were differently expressed in COVID-19 patients with different severity. The results showed that the expression of OASI, MX1, PKR, and ISG15 genes was significantly (P=0.001) lower in severe patients. Conclusions: Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.

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