Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice

Cuicui Duan; Yujuan Zhao; Cheng Huang; Zijian Zhao; Lei Gao; Chunhua Niu; Chao Wang; Xiaoxiao Liu; Chuan Zhang; Shengyu Li

Journal of Functional Foods (Apr 2018)

Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN–induced acute liver injury in mice

Cuicui Duan,
Yujuan Zhao,
Cheng Huang,
Zijian Zhao,
Lei Gao,
Chunhua Niu,
Chao Wang,
Xiaoxiao Liu,
Chuan Zhang,
Shengyu Li

Affiliations

Cuicui Duan: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Yujuan Zhao: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Cheng Huang: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Zijian Zhao: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Lei Gao: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Chunhua Niu: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Chao Wang: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Xiaoxiao Liu: Institute of Agricultural Quality Standard and Testing Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China
Chuan Zhang: Department of Endocrinology, The Second Hospital of Jilin University, Changchun 130000, PR China; Corresponding authors at: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, No. 1363 Sheng-Tai Street, Changchun, Jilin Province 130033, PR China (S. Li). Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin Province, PR China (C. Zhang).
Shengyu Li: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China; Corresponding authors at: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, No. 1363 Sheng-Tai Street, Changchun, Jilin Province 130033, PR China (S. Li). Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin Province, PR China (C. Zhang).

Journal volume & issue: Vol. 43
pp. 146 – 153

Abstract

Read online

Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN–induced liver injury. L. plantarum C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-κB nuclear translocations and P65, P38 phosphorylation levels. Moreover, L. plantarum C88 enhanced the intestinal mucosal barrier by upregulating the expressions of tight junction proteins as well as HIF-1α. These results suggest that L. plantarum C88 protects against ALF associated with Nrf2 and the MAPK/NF-κB signaling pathways.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords