H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines

Abstract

Avian flu: Vaccines struggle to elicit strong immune response Evidence shows that vaccines for avian flu provoke a poorer immune response than those for seasonal human flu. Avian influenza is an emergent disease that poses a credible threat to public health, yet vaccines to treat avian flu have not performed well in clinical trials. A team of scientists led by Richard Webby of St Jude Children’s Research Hospital, United States, investigated the reasons for this by comparing vaccine’s ability to stimulate the immune system in comparison to a vaccine to treat seasonal human flu. In contrast to previous hypotheses, Webby’s group found that only the avian H5N1 flu vaccine provoked a lesser release of neutralizing antibodies compared to the H7N9 (another avian flu) and seasonal flu vaccine, and hypothesized that differences in viral surface proteins may account for the difference. The authors hope this helps to direct future research into vaccine-induced immunity.