Protopanaxatriol-type saponin protects against acetaminophen-induced liver injury through ROS-mediated JNK pathway

Linlin Qu; Rongzhan Fu; Xiaoxuan Ma; Daidi Fan

Journal of Functional Foods (Nov 2021)

Protopanaxatriol-type saponin protects against acetaminophen-induced liver injury through ROS-mediated JNK pathway

Linlin Qu,
Rongzhan Fu,
Xiaoxuan Ma,
Daidi Fan

Affiliations

Linlin Qu: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China
Rongzhan Fu: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China
Xiaoxuan Ma: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China
Daidi Fan: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China; Corresponding author at: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China.

Journal volume & issue: Vol. 86
p. 104672

Abstract

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Worldwide, drug-induced acute liver failure is associated with a high rate of morbidity and mortality. Acetaminophen (APAP), a widely used analgesic, is one of the most common causes of acute liver injury. The purpose of this study was to determine the protective effect of protopanaxatriol-type saponin (PTS) against APAP-induced liver injury and to elucidate the mechanisms underlying this effect. Mice were pretreated with PTS via gavage for 7 days prior to receiving APAP. The results indicated that PTS was highly effective in preventing hepatotoxicity caused by APAP. Meanwhile, pretreatment with PTS resulted in a decrease in inflammation and oxidative stress. Furthermore, PTS reversed the histological change and reduced hepatic injury. Additionally, PTS inhibited the expression of proteins associated with APAP induced hepatic apoptosis in the liver. Taken together, our findings indicated that PTS protected against liver injury caused by APAP by alleviating oxidative stress, inflammation, and apoptosis via the ROS-mediated JNK pathway. Our findings suggest that PTS may have the potential as a novel therapeutic agent for APAP-induced liver injury.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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