npj Vaccines (May 2021)
ChAdOx1 nCoV-19 (AZD1222) vaccine candidate significantly reduces SARS-CoV-2 shedding in ferrets
- Glenn A. Marsh,
- Alexander J. McAuley,
- Gough G. Au,
- Sarah Riddell,
- Daniel Layton,
- Nagendrakumar B. Singanallur,
- Rachel Layton,
- Jean Payne,
- Peter A. Durr,
- Hannah Bender,
- Jennifer A. Barr,
- John Bingham,
- Victoria Boyd,
- Sheree Brown,
- Matthew P. Bruce,
- Kathie Burkett,
- Teresa Eastwood,
- Sarah Edwards,
- Tamara Gough,
- Kim Halpin,
- Jenni Harper,
- Clare Holmes,
- William S. J. Horman,
- Petrus Jansen van Vuren,
- Suzanne Lowther,
- Kate Maynard,
- Kristen D. McAuley,
- Matthew J. Neave,
- Timothy Poole,
- Christina Rootes,
- Brenton Rowe,
- Elisha Soldani,
- Vittoria Stevens,
- Cameron R. Stewart,
- Willy W. Suen,
- Mary Tachedjian,
- Shawn Todd,
- Lee Trinidad,
- Duane Walter,
- Naomi Watson,
- Trevor W. Drew,
- Sarah C. Gilbert,
- Teresa Lambe,
- S. S. Vasan
Affiliations
- Glenn A. Marsh
- CSIRO Australian Centre for Disease Preparedness
- Alexander J. McAuley
- CSIRO Australian Centre for Disease Preparedness
- Gough G. Au
- CSIRO Australian Centre for Disease Preparedness
- Sarah Riddell
- CSIRO Australian Centre for Disease Preparedness
- Daniel Layton
- CSIRO Australian Centre for Disease Preparedness
- Nagendrakumar B. Singanallur
- CSIRO Australian Centre for Disease Preparedness
- Rachel Layton
- CSIRO Australian Centre for Disease Preparedness
- Jean Payne
- CSIRO Australian Centre for Disease Preparedness
- Peter A. Durr
- CSIRO Australian Centre for Disease Preparedness
- Hannah Bender
- CSIRO Australian Centre for Disease Preparedness
- Jennifer A. Barr
- CSIRO Australian Centre for Disease Preparedness
- John Bingham
- CSIRO Australian Centre for Disease Preparedness
- Victoria Boyd
- CSIRO Australian Centre for Disease Preparedness
- Sheree Brown
- CSIRO Australian Centre for Disease Preparedness
- Matthew P. Bruce
- CSIRO Australian Centre for Disease Preparedness
- Kathie Burkett
- CSIRO Australian Centre for Disease Preparedness
- Teresa Eastwood
- CSIRO Australian Centre for Disease Preparedness
- Sarah Edwards
- CSIRO Australian Centre for Disease Preparedness
- Tamara Gough
- CSIRO Australian Centre for Disease Preparedness
- Kim Halpin
- CSIRO Australian Centre for Disease Preparedness
- Jenni Harper
- CSIRO Australian Centre for Disease Preparedness
- Clare Holmes
- CSIRO Australian Centre for Disease Preparedness
- William S. J. Horman
- CSIRO Australian Centre for Disease Preparedness
- Petrus Jansen van Vuren
- CSIRO Australian Centre for Disease Preparedness
- Suzanne Lowther
- CSIRO Australian Centre for Disease Preparedness
- Kate Maynard
- CSIRO Australian Centre for Disease Preparedness
- Kristen D. McAuley
- CSIRO Australian Centre for Disease Preparedness
- Matthew J. Neave
- CSIRO Australian Centre for Disease Preparedness
- Timothy Poole
- CSIRO Australian Centre for Disease Preparedness
- Christina Rootes
- CSIRO Australian Centre for Disease Preparedness
- Brenton Rowe
- CSIRO Australian Centre for Disease Preparedness
- Elisha Soldani
- CSIRO Australian Centre for Disease Preparedness
- Vittoria Stevens
- CSIRO Australian Centre for Disease Preparedness
- Cameron R. Stewart
- CSIRO Australian Centre for Disease Preparedness
- Willy W. Suen
- CSIRO Australian Centre for Disease Preparedness
- Mary Tachedjian
- CSIRO Australian Centre for Disease Preparedness
- Shawn Todd
- CSIRO Australian Centre for Disease Preparedness
- Lee Trinidad
- CSIRO Australian Centre for Disease Preparedness
- Duane Walter
- CSIRO Australian Centre for Disease Preparedness
- Naomi Watson
- CSIRO Australian Centre for Disease Preparedness
- Trevor W. Drew
- CSIRO Australian Centre for Disease Preparedness
- Sarah C. Gilbert
- Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Teresa Lambe
- Jenner Institute, Nuffield Department of Medicine, University of Oxford
- S. S. Vasan
- CSIRO Australian Centre for Disease Preparedness
- DOI
- https://doi.org/10.1038/s41541-021-00315-6
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 8
Abstract
Abstract Vaccines against SARS-CoV-2 are likely to be critical in the management of the ongoing pandemic. A number of candidates are in Phase III human clinical trials, including ChAdOx1 nCoV-19 (AZD1222), a replication-deficient chimpanzee adenovirus-vectored vaccine candidate. In preclinical trials, the efficacy of ChAdOx1 nCoV-19 against SARS-CoV-2 challenge was evaluated in a ferret model of infection. Groups of ferrets received either prime-only or prime-boost administration of ChAdOx1 nCoV-19 via the intramuscular or intranasal route. All ChAdOx1 nCoV-19 administration combinations resulted in significant reductions in viral loads in nasal-wash and oral swab samples. No vaccine-associated adverse events were observed associated with the ChAdOx1 nCoV-19 candidate, with the data from this study suggesting it could be an effective and safe vaccine against COVID-19. Our study also indicates the potential for intranasal administration as a way to further improve the efficacy of this leading vaccine candidate.
