Leveraging protein binding and the EPR effect in legacy chemotherapy regimens

Abstract

Legacy chemotherapy regimens have the potential to be significantly more effective and less toxic if the dosage is titrated so that the mole ratio of drugs to circulating albumin is less than or equal to 1 and the order of administration of the drugs within each course of the regimen follows the sequence most hydrophobic (usually the least dose) to least hydrophobic (usually the largest dose)