Protective effect of quercetin and chlorogenic acid, two polyphenols widely present in edible plant varieties, on visible light-induced retinal degeneration in vivo

Yong Wang; Liang Zhao; Chengtao Wang; Jimei Hu; Xiaoxuan Guo; Di Zhang; Wei Wu; Feng Zhou; Baoping Ji

Journal of Functional Foods (Jun 2017)

Protective effect of quercetin and chlorogenic acid, two polyphenols widely present in edible plant varieties, on visible light-induced retinal degeneration in vivo

Yong Wang,
Liang Zhao,
Chengtao Wang,
Jimei Hu,
Xiaoxuan Guo,
Di Zhang,
Wei Wu,
Feng Zhou,
Baoping Ji

Affiliations

Yong Wang: Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, People’s Republic of China
Liang Zhao: Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, People’s Republic of China
Chengtao Wang: Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University, Beijing, People’s Republic of China
Jimei Hu: China International Engineering Consulting Corporation, Beijing, People’s Republic of China
Xiaoxuan Guo: Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, People’s Republic of China
Di Zhang: School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, People’s Republic of China
Wei Wu: College of Engineering, China Agricultural University, Beijing, People’s Republic of China
Feng Zhou: Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, People’s Republic of China; Corresponding authors.
Baoping Ji: Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, People’s Republic of China; Corresponding authors.

Journal volume & issue: Vol. 33
pp. 103 – 111

Abstract

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The protective effect of quercetin and chlorogenic acid (CA) on visible light-induced retinal damage was investigated in pigmented rabbits. Quercetin and CA effectively suppressed the levels of oxidative stress markers increased by light exposure and significantly increased the levels of heme oxygenase-1 in retina (p < 0.05). The levels of inflammatory cytokines, including monocyte chemoattractant protein 1, interleukin (IL)-8, IL-1 β, tumour necrosis factor-alpha, cyclooxygenase 2 and inducible nitric oxide synthase in retinal tissues, were significantly reduced by quercetin and CA; additionally, quercetin significantly inhibited the expression of nuclear factor kappa B (p < 0.05). Moreover, photooxidative stress-induced changes in expression levels of apoptotic proteins and angiogenesis factors were regulated by quercetin and CA. Histological analysis revealed that the thickness of the outer nuclear layer was maintained by quercetin but not by CA. Results suggest that quercetin and CA play an important role in alleviating retinal degeneration.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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