Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities

Yan Bai; Dahong Li; Tingting Zhou; Ningbo Qin; Zhanlin Li; Zhiguo Yu; Huiming Hua

Journal of Functional Foods (Jan 2016)

Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities

Yan Bai,
Dahong Li,
Tingting Zhou,
Ningbo Qin,
Zhanlin Li,
Zhiguo Yu,
Huiming Hua

Affiliations

Yan Bai: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Dahong Li: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Processes, Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang 222001, China
Tingting Zhou: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Ningbo Qin: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Zhanlin Li: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Zhiguo Yu: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding author. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 024 23986295; fax: +86 024 23986295.
Huiming Hua: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding author. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 024 23986465; fax: +86 024 23986465.

Journal volume & issue: Vol. 20
pp. 453 – 462

Abstract

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Angelica dahurica has been frequently used as a food additive and a folk medicinal herb in Asian countries. The aim of this study was to isolate key active compounds from A. dahurica with antioxidant and anticancer activities. Three new furocoumarin dimers and twenty known coumarins were obtained from A. dahurica. Their structures were identified by extensive 1D and 2D NMR, CD, and HR-ESIMS spectroscopic analyses and screened by UPLC-MS/MS. Imperatorin oxypeucedanin hydrate, xanthotoxol, bergaptol, and 5-methoxy-8-hydroxypsoralen exhibited moderate DPPH• scavenging activity and strong ABTS•+ scavenging activity. Isoimperatorin, phelloptorin, and pabularinone showed significant inhibition on HepG2 cells with IC50 values of 8.19, 7.49, and 7.46 µM, respectively. Furthermore, pabularinone also showed moderate inhibition on HeLa cells with an IC50 value of 13.48 µM. These results suggested that A. dahurica could be explored as new and potential natural antioxidants and cancer prevention agents for use in functional foods.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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