Lotus seed resistant starch decreases the blood lipid and regulates the serum bile acids profiles in hyperlipidemic rats

Suzhen Lei; Lu Liu; Peiyu Yue; Baodong Zheng; Yi Zhang; Hongliang Zeng

Journal of Functional Foods (May 2022)

Lotus seed resistant starch decreases the blood lipid and regulates the serum bile acids profiles in hyperlipidemic rats

Suzhen Lei,
Lu Liu,
Peiyu Yue,
Baodong Zheng,
Yi Zhang,
Hongliang Zeng

Affiliations

Suzhen Lei: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Lu Liu: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Peiyu Yue: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Baodong Zheng: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Yi Zhang: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Corresponding authors at: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Hongliang Zeng: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Corresponding authors at: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Journal volume & issue: Vol. 92
p. 105040

Abstract

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We investigated the effects of lotus seed resistant starch (LRS) on blood lipid lowering and serum bile acids profiles of hyperlipidemic rats, and construct the relationship between serum lipid profile and bile acids. Normal rats or hyperlipidemic rats were gavage with LRS for consecutive 4 weeks. The results showed that LRS slowed down the weight gain and liver index increase in hyperlipidemic rats, alleviated fatty liver symptoms, and improved blood lipid levels. Furthermore, bile acid-targeted metabolomics and correlation analysis showed that T-α-MCA and GDCA had negative correlation with HDL-C, while β-MCA and ω-MCA had positive correlation with TG. HCA and isoLCA had positive correlation with TG, TCHO and LDL-C. In short, LRS inhibited the reabsorption of T-α-MCA, β-MCA, ω-MCA, HCA, isoLCA and GDCA, and reduced their content in serum to improved blood lipid in hyperlipidemic rats. Meanwhile T-α-MCA, β-MCA, HCA and isoLCA may be potential biomarkers for screening of hyperlipidemia.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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