Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

HUANG Aodi, YAN Jiahui, ZHANG Zhaohuan, LIU Haiquan, ZHAO Yong, OU Jie

doi:10.7506/spkx1002-6630-20230328-273

Shipin Kexue (Feb 2024)

Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

HUANG Aodi, YAN Jiahui, ZHANG Zhaohuan, LIU Haiquan, ZHAO Yong, OU Jie

Affiliations

HUANG Aodi, YAN Jiahui, ZHANG Zhaohuan, LIU Haiquan, ZHAO Yong, OU Jie: (1. College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China;2. Shanghai Engineering Research Center of Aquatic Product Processing & Preservation, Shanghai 201306, China; 3. Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Rural Affairs, Shanghai 201306, China)

DOI: https://doi.org/10.7506/spkx1002-6630-20230328-273
Journal volume & issue: Vol. 45, no. 3
pp. 61 – 67

Abstract

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This study aimed to construct a dose-response model of aflatoxin B1 (AFB1)-induced apoptosis rate in rat hepatocytes by using quantitative data. The coefficients of determination (R2) and further mathematical tests showed that the Gamma model (R2 = 0.996 4, Akaike information criterion = 37.40, and Bayesian information criterion = 17.19) was superior to other models. Hence, the Gamma model was recommended as the optimal dose-response model for apoptosis rate in rat hepatocytes after acute exposure to AFB1 for hazard characterization in the framework of AFB1 risk assessment.

aflatoxin b1; hepatocyte apoptosis; risk assessment; dose-response model

Published in Shipin Kexue

ISSN: 1002-6630 (Print)
Publisher: China Food Publishing Company
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture
Website: https://www.spkx.net.cn/EN/1002-6630/home.shtml

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