Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice

Fred Kwame Ofosu; Fazle Elahi; Eric Banan-Mwine Daliri; Simon Okomo Aloo; Ramachandran Chelliah; Sang-Ik Han; Deog-Hwan Oh

Journal of Functional Foods (Aug 2023)

Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice

Fred Kwame Ofosu,
Fazle Elahi,
Eric Banan-Mwine Daliri,
Simon Okomo Aloo,
Ramachandran Chelliah,
Sang-Ik Han,
Deog-Hwan Oh

Affiliations

Fred Kwame Ofosu: Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, South Korea
Fazle Elahi: Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, South Korea; Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO, USA
Eric Banan-Mwine Daliri: Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Simon Okomo Aloo: Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, South Korea
Ramachandran Chelliah: Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, South Korea; Department of Food Science and Biotechnology, Kangwon Institute of Inclusive Technology (KIIT), Kangwon National University, Gangwon-do 24341, South Korea
Sang-Ik Han: Department of of Southern Area Crop Science, NICS Upland Crop Breeding Res. Div., Gyeongsangnaam-do 50424, South Korea
Deog-Hwan Oh: Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, South Korea; Corresponding author at: Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, South Korea.

Journal volume & issue: Vol. 107
p. 105666

Abstract

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Microbial metabolites play key roles in the pathogenesis of insulin resistance and type 2 diabetes (T2D). A preliminary study on the impact of fermented sorghum (FS) on T2D and its modulation of gut microbiota and their metabolites was assessed using 16S rRNA gene sequencing and metabolomics. FS supplementation ameliorated hyperglycemia, insulin resistance and reversed the abundance of opportunistic pathogenic bacteria (such as Oscillibcater, Acetatifactor and Acetivibrio) positively associated with T2D. FS promoted the growth of beneficial bacteria (Muribaculum, Parabacteroides and Phocaeicola) positively correlated with fecal butyrate and propionate inversely associated with T2D. FS decreased the serum concentration of microbial metabolites (p-cresol sulfate, indolelactate, indoxyl sulfate, indole-3-aldehyde). FS increased the levels of phenylpropionate, phenyl sulfate, valine, bile acids (taurocholic acid, ursodeoxycholic acid and cholic acid) inversely associated with T2D. The beneficial effect of fermented sorghum on T2D remission could be attributed to modulation of gut microbiota and its related-metabolites.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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