Effects of probiotic supplementation on cardiovascular risk factors in hypercholesterolemia: A systematic review and meta-analysis of randomized clinical trial

Jinchi Jiang; Caie Wu; Chengcheng Zhang; Jianxin Zhao; Leilei Yu; Hao Zhang; Arjan Narbad; Wei Chen; Qixiao Zhai

Journal of Functional Foods (Nov 2020)

Effects of probiotic supplementation on cardiovascular risk factors in hypercholesterolemia: A systematic review and meta-analysis of randomized clinical trial

Jinchi Jiang,
Caie Wu,
Chengcheng Zhang,
Jianxin Zhao,
Leilei Yu,
Hao Zhang,
Arjan Narbad,
Wei Chen,
Qixiao Zhai

Affiliations

Jinchi Jiang: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Caie Wu: College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China
Chengcheng Zhang: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Jianxin Zhao: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Leilei Yu: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Hao Zhang: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China
Arjan Narbad: International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China; Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park Colney, Norwich, UK
Wei Chen: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China
Qixiao Zhai: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China; Corresponding author at: No. 1800, Lihu Avenue, Binhu District, Wuxi, Jiangsu 214122, China.

Journal volume & issue: Vol. 74
p. 104177

Abstract

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The aim of this meta-analysis was to assess the effects of probiotic consumption on the lipid profiles of hypercholesterolemic patients in randomized controlled trials (RCT). We performed systematic searches in The Cochrane Library, Web of Science, Medline and Google Scholar for relevant studies published up to March 2020. Of the 2346 reports that were screened, 13 randomized clinical trials were selected. The pooled data revealed that probiotic supplementation significantly (p < 0.05) decreased total cholesterol (TC) [n = 20; standardized mean difference (SMD) = −0.30; 95% confidence interval (CI): −0.43, −0.16; p < 0.0001] and low-density lipoprotein cholesterol (LDL-C) levels (n = 20; SMD = −0.32; 95% CI: −0.46, −0.19; p < 0.00001) in hypercholesterolemic patients. We found that the administration of probiotics counteracted some aspects of dyslipidemia in hypercholesterolemic patients.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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