Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice

Abstract

Alcoholic liver disease is one of the most prevalent chronic diseases that causes high morbidity and mortality worldwide. This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice. BSPs were rich in oligopeptides (80%, w/w, 0.05). All treatments significantly (P < 0.01) reduced the creatinine level compared to the model group. The histopathological examination further confirmed the protective effect of BSPs. This protective effect is possibly attributed to the antioxidant and anti-inflammatory activities of BSPs due to the increased levels of GSH, SOD and CAT and decreased contents of MDA, IL-6 and IL-1β compared to those of model group.

Keywords

• Alcalase
• Bioactive peptides
• Alcoholic liver injury
• Antioxidant
• Anti-inflammation
• Amino acid composition