Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats

Tingting Wang; Lin Zheng; Shuguang Wang; Mouming Zhao; Xiaoling Liu

Food Science and Human Wellness (Nov 2022)

Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats

Tingting Wang,
Lin Zheng,
Shuguang Wang,
Mouming Zhao,
Xiaoling Liu

Affiliations

Tingting Wang: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China
Lin Zheng: Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Shuguang Wang: Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Mouming Zhao: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Corresponding authors at: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
Xiaoling Liu: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Corresponding authors at: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China

Journal volume & issue: Vol. 11, no. 6
pp. 1614 – 1622

Abstract

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The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting blood glucose level and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance and plasma lipid level in diabetic rats were also alleviated. Furthermore, histological analysis showed that SCGH effectively protected the tissue structure of liver. In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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