Regulation of the Cyanide-Resistant Alternative Respiratory Pathway in the Fungus Acremonium chrysogenum

Abstract

This review summarises the current knowledge on the biochemical and physiological events that directly or indirectly alter the engagement of the cyanide-resistant alternative respiratory pathway in the cephalosporin C producer filamentous fungus Acremonium chrysogenum. Particular emphasis is placed on the role this activity plays in the overproduction of antibiotic, and also on the critical fermentation technology background that supports its operation.

Keywords

• Acremonium chrysogenum
• alternative oxidase
• respiration
• peroxides
• cephalosporin C
• soybean oil