Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources

Xiaolong Ji; Jianhang Guo; Tengzheng Cao; Tingting Zhang; Yanqi Liu; Yizhe Yan

Food Science and Human Wellness (Nov 2023)

Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources

Xiaolong Ji,
Jianhang Guo,
Tengzheng Cao,
Tingting Zhang,
Yanqi Liu,
Yizhe Yan

Affiliations

Xiaolong Ji: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450001, China; Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001,China
Jianhang Guo: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China
Tengzheng Cao: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China
Tingting Zhang: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China
Yanqi Liu: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450001, China; Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001,China; Correspondence authors at: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China
Yizhe Yan: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450001, China; Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001,China; Food Laboratory of Zhongyuan, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Correspondence authors at: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China

Journal volume & issue: Vol. 12, no. 6
pp. 1969 – 1980

Abstract

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Diabetes mellitus (DM) is a common multifactorial disease, causing various complications, such as chronic metabolism. The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect. However, polysaccharides mainly extracted from natural resources, have advantages of safety, accessibility, and anti-diabetic potential. We have summarized recent research of natural polysaccharides with hypoglycemic activities, focusing on different pharmacological mechanisms in various cell and animal models. The relationships of structure-hypoglycemic effect are also discussed in detail. This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus, which have been required by clinical studies yet.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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