EPA enriched ethanolamine plasmalogens significantly improve cognition of Alzheimer’s disease mouse model by suppressing β-amyloid generation

Hongxia Che; Miaomiao Zhou; Tiantian Zhang; Lingyu Zhang; Lin Ding; Teruyoshi Yanagita; Jie Xu; Changhu Xue; Yuming Wang

Journal of Functional Foods (Feb 2018)

EPA enriched ethanolamine plasmalogens significantly improve cognition of Alzheimer’s disease mouse model by suppressing β-amyloid generation

Hongxia Che,
Miaomiao Zhou,
Tiantian Zhang,
Lingyu Zhang,
Lin Ding,
Teruyoshi Yanagita,
Jie Xu,
Changhu Xue,
Yuming Wang

Affiliations

Hongxia Che: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China
Miaomiao Zhou: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China
Tiantian Zhang: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China
Lingyu Zhang: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China
Lin Ding: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China
Teruyoshi Yanagita: Department of Health and Nutrition Science, Nishikyushu University, Kanzaki, Japan
Jie Xu: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China
Changhu Xue: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China; Qingdao National Laboratory for Marine Science and Technology, Laboratory of Marine Drugs & Biological Products, Qingdao 266237, Shandong, China; Corresponding authors at: College of Food Science and Engineering, Ocean University of China, China.
Yuming Wang: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, China; Qingdao National Laboratory for Marine Science and Technology, Laboratory of Marine Drugs & Biological Products, Qingdao 266237, Shandong, China; Corresponding authors at: College of Food Science and Engineering, Ocean University of China, China.

Journal volume & issue: Vol. 41
pp. 9 – 18

Abstract

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EPA enriched ethanolamine plasmalogens (EPA-pPE) are important bioactive components and widely distributed in multifarious marine products. In the present study, Chinese hamster ovary cells stably transfected with APP751 and PS1 (CHO-APP/PS1 cells) and high-fat feeding SAMP8 mice were used to study the effects of EPA-pPE on Alzheimer’s disease (AD). The in vitro experiments showed that EPA-pPE exerted better effects than EPA-PE and Egg-PE in decreasing the intracellular and extracellular Aβ levels. EPA-pPE obviously improved learning and memory function of high-fat feeding SAMP8 mice by Morris maze test. Further mechanism research indicated that EPA-pPE could significantly improve cognition of Alzheimer’s disease by suppressing β-amyloid generation via reducing levels of APP and altering APP cleavage, thereby inhibiting oxidative stress, hyper-phosphorylated tau, neuro-inflammation and apoptosis. These results suggested that EPA-pPE might be applied as food supplements and/or functional ingredients to relieve neurodegenerative disease.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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