Partridge tea polyphenols alleviated STZ-induced diabetic nephropathy by regulating Keap1/Nrf2/ARE signaling pathway in C57BL/6 mice

Mantong Zhao; Keke Meng; Meihui Zhao; Haohao Shi; Zhongyuan Liu; Yonghuan Yun; Weimin Zhang; Zhouwei Duan; Guanghua Xia

Journal of Functional Foods (Apr 2024)

Partridge tea polyphenols alleviated STZ-induced diabetic nephropathy by regulating Keap1/Nrf2/ARE signaling pathway in C57BL/6 mice

Mantong Zhao,
Keke Meng,
Meihui Zhao,
Haohao Shi,
Zhongyuan Liu,
Yonghuan Yun,
Weimin Zhang,
Zhouwei Duan,
Guanghua Xia

Affiliations

Mantong Zhao: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Keke Meng: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Meihui Zhao: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Haohao Shi: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Zhongyuan Liu: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Yonghuan Yun: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Weimin Zhang: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China
Zhouwei Duan: Institute of Processing & Design of Agroproducts, Hainan Academy of Agricultural Science, Haikou 570228, China
Guanghua Xia: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, Engineering Research Center of Utilization of Tropical Polysaccharide Resources of MOE, College of Food Science and Technology, Hainan University, Haikou 570228, China; Corresponding author.

Journal volume & issue: Vol. 115
p. 106127

Abstract

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The present work investigated the effect of Partridge tea polyphenols (PTP) on streptozotocin (STZ)‑induced diabetic mice as well as the underlying mechanism with rosiglitazone as positive control. Administration with PTP (250 or 500 mg/kg) for 5 weeks, compared to the diabetic nephropathy control group (DC group), PTP significantly decreased the renal index, creatinine in serum and urine, urea nitrogen and proteinuria and alleviated histopathological injury of renal tissue. The levels of TNF-α, IL-1β and IL-6 were decreased and SOD, CAT activities were increased by PTP. PTP significantly reduced the FN and COL-IV levels. Moreover, PTP significantly inhibited the Keap1 mRNA level of Keap1 and the corresponding protein expression, while increased the mRNA levels of Nrf2, HO-1, NQO1 and the corresponding protein expression. Therefore, PTP could reverse renal injury, enhance renal functions, inhibit renal oxidative stress, and activate Keap1/Nrf2/ARE signaling pathway to alleviative diabetic nephropathy.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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