Modulation of the gut microbiota alleviates insulin resistance in type 2 diabetic mice by daucosterol from Eleocharis dulcis peel

Xiaomei Yang; Yipeng Gu; Huazhong Liu; Feifei Shang; Tomoyuki Koyama

Journal of Functional Foods (Mar 2024)

Modulation of the gut microbiota alleviates insulin resistance in type 2 diabetic mice by daucosterol from Eleocharis dulcis peel

Xiaomei Yang,
Yipeng Gu,
Huazhong Liu,
Feifei Shang,
Tomoyuki Koyama

Affiliations

Xiaomei Yang: Guangxi Key Laboratory of Health Care Food Science and Technology, Institute of Food Science and Technology, Hezhou University, Hezhou 542899, China
Yipeng Gu: Guangxi Key Laboratory of Health Care Food Science and Technology, Institute of Food Science and Technology, Hezhou University, Hezhou 542899, China; Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan; Corresponding authors at: Guangxi Key Laboratory of Health Care Food Science and Technology, Institute of Food Science and Technology, Hezhou University, Hezhou 542899, China (Y. Gu). Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan (T. Koyama).
Huazhong Liu: College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China
Feifei Shang: Guangxi Key Laboratory of Health Care Food Science and Technology, Institute of Food Science and Technology, Hezhou University, Hezhou 542899, China
Tomoyuki Koyama: Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan; Corresponding authors at: Guangxi Key Laboratory of Health Care Food Science and Technology, Institute of Food Science and Technology, Hezhou University, Hezhou 542899, China (Y. Gu). Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan (T. Koyama).

Journal volume & issue: Vol. 114
p. 106092

Abstract

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Daucosterol, a natural saponin from Eleocharis dulcis peel, exhibited anti-hyperglycemic properties. This study investigated daucosterol's effects on glycemic control, insulin resistance, and gut microbiota in type 2 diabetic mice. The results demonstrated that daucosterol treatment reduced fasting glucose, improved glucose intolerance and pancreatic islet damage. It decreased HOMA-IR and increased ISI, indicating enhanced insulin sensitivity. Daucosterol supplementation enriched gut microbiota diversity, including reducing Firmicutes and Desulfobacterota while increasing Bacteroidia. This involved an increase in Enterococcus, Akkermansia, Alistipes, Clostridium_sensu_stricto_1, and Odoribacter, coupled with decreased Aerococcus, Desulfovibrio, and Blautia, improved gut health. Uncultured_bacterium_g_Clostridium_sensu_stricto_1 and Bifidobacterium_pseudolongum were identified as major biomarkers. PICRUSt analysis revealed daucosterol improved the pathways of glycan biosynthesis and metabolism, lipid metabolism, carbohydrate metabolism, and some organismal systems. Therefore, daucosterol act as a potential anti-hyperglycemic agent, improving insulin resistance and optimizing gut microbiota to alleviate type 2 diabetes.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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