Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague–Dawley rats?

Hokuto Nakata; Shouta M.M. Nakayama; Andrew Kataba; Haruya Toyomaki; Rio Doya; Yared Beyene Yohannes; Yoshinori Ikenaka; Mayumi Ishizuka

Journal of Functional Foods (Oct 2022)

Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague–Dawley rats?

Hokuto Nakata,
Shouta M.M. Nakayama,
Andrew Kataba,
Haruya Toyomaki,
Rio Doya,
Yared Beyene Yohannes,
Yoshinori Ikenaka,
Mayumi Ishizuka

Affiliations

Hokuto Nakata: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
Shouta M.M. Nakayama: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia
Andrew Kataba: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia
Haruya Toyomaki: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
Rio Doya: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
Yared Beyene Yohannes: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan; Department of Chemistry, College of Natural and Computational Science, University of Gondar, P.O. Box 196, Gondar, Ethiopia
Yoshinori Ikenaka: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan; Water Research Group, School of Environmental Sciences and Development, North-West University, South Africa
Mayumi Ishizuka: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan; Corresponding author at: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan.

Journal volume & issue: Vol. 97
p. 105242

Abstract

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Moringa Oleifera (MO) has potential for nutritional and medical applications. We verified whether the administration of MO changed mineral accumulation patterns and mitigative effects of lead poisoning using Sprague–Dawley rats. MO leaves, aqueous leaf extracts, and seeds were administrated to rats in two different concentrations (100 and 600 mg/kg body weight/day) for 3 weeks. Element analysis, biochemical blood tests, oxidative-stress assessment, and blood δ-aminolevulinic acid dehydratase (ALAD) activity assays were performed after euthanasia and dissection. Although apparent changes in element accumulation patterns and biochemical parameters for hepatic and renal function assessments were not observed, lead-induced oxidative stress was significantly mitigated by the administration of MO leaves. The administration of high-dose MO leaves and seeds significantly recovered ALAD activity. Further investigations for potential mitigative effects of MO on lead toxicity and its mechanism are required.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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