Advance in Understanding the Effect of β-Nicotinamide Mononucleotide on Physiological Functions

Abstract

The overweight or obese population in sub-health status and the aging population in China are increasing year by year. The intracellular level of nicotinamide adenine dinucleotide (NAD+) decreases dramatically with age and obesity. NAD+ is the key target of cellular energy metabolism and cell function regulation, which affects senescence. Therefore, improving physiological functions and delay aging by supplementing NAD+ precursors has become a hot topic of current research. β-Nicotinamide mononucleotide (NMN) is an intermediate metabolite of NAD+ in animals, and it is also the most direct and efficient NAD+ supplement precursor at present. However, NMN has complex effects on the physiological functions of various organs, the results of animal tests are not consistent with those of human clinical tests, and the optimal dosage has not been determined. This paper summarizes the results of recent animal and human clinical tests of NMN aiming to explore the effects, mechanisms, doses and adverse reactions of NMN supplementation on animal and human physiological functions. Through this paper, we hope to provide ideas for future research and application of NMN.

Keywords

• β-nicotinamide mononucleotide; nicotinamide adenine dinucleotide metabolism; animal tests; human clinical trials; physiological functions