Genistein effectiveness in improvement of glucose and lipid metabolism and homocysteine levels: A systematic review and meta-analysis

Abstract

This study was performed to assess the effect of genistein supplementation in improving glycemic indices, lipid profiles, and homocysteine. A comprehensive systemic search was performed on PubMed-Medline, SCOPUS, Web of Science and Embase databases, and Google Scholar databases. Results showed a significant decrease in BMI (WMD = -0.19 kg/m2; 95 % CI: −0.36, −0.02), FBS (WMD = -6.2 mg/dl; 95 % CI: −8.93, −3.47), insulin level (WMD = -1.61 µU/ml; 95 % CI: −2.20, −1.01), HOMA-IR (WMD = -0.65; 95 % CI: −0.83, −0.47), TG (WMD = -21.55 mg/dl; 95 % CI: –33.83, −9.27), TC (WMD = -8.10 mg/dl; 95 % CI: −14.94, −1.26), and Hcy (WMD = -1.02 mg/dl; 95 % CI: −1.86, −0.18), but not LDL-C levels (WMD = -10.68 mg/dl; 95 % CI: −24.29, 2.93). As well as the level of HDL-C was increased significantly (WMD = 3.34 mg/dl; 95 % CI: 1.24, 5.43). Genistein supplementation had significant beneficial effects on glucose and lipid metabolism as well as homocysteine levels and may be helpful in the control of metabolic status.

Keywords

• Genistein
• Glucose metabolism
• Lipid metabolism
• Homocysteine
• Systematic review
• Meta-analysis